Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 56621-48-8, is researched, Molecular C10H14N2O, about Synthesis and bioevaluation of 4,5,6,7-tetrahydrobenzo[d]isoxazole derivatives as melanogenesis inhibitors, the main research direction is arylpiperazinyl tetrahydrobenzoisoxazolyl methanone preparation melanogenesis inhibitor SAR; tetrahydrobenzoisoxalyl carboxylic acid chloride preparation arylpiperazine amide coupling.Computed Properties of C10H14N2O.
A series of 4,5,6,7-tetrahydrobenzo[d]isoxazole derivatives I [R1 = H, tert-butyl; R2 = 4-OH, 4-OMe, 2-OMe, 4-CF3, 4-F] was prepared via amide coupling of arylpiperazines with corresponding 4,5,6,7-tetrahydrobenzo[d]isoxazole carboxylic acid chlorides. Addnl., 4,5,6,7-tetrahydrobenzo[d]isoxazole derivative I [R1 = H; R2 = 4-OEt] was synthesized by O-alkylation of compound I [R1 = H; R2 = 4-OH] using iodoethane. The synthesized compounds were tested for their melanogenesis inhibiting activity through potential down-regulation of tyrosinase expression. Among the tested compounds, compounds I [R1 = H; R2 = 4-OMe, 2-OMe, 4-CF3] displayed better melanogenesis inhibiting activity than well-known compounds Arbutin and Kojic acid, without intrinsic cytotoxicity.
In addition to the literature in the link below, there is a lot of literature about this compound(4-(Piperazin-1-yl)phenol)Computed Properties of C10H14N2O, illustrating the importance and wide applicability of this compound(56621-48-8).
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem