The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(Piperazin-1-yl)phenol(SMILESS: OC1=CC=C(N2CCNCC2)C=C1,cas:56621-48-8) is researched.SDS of cas: 56621-48-8. The article 《Discovery of small molecules that inhibit melanogenesis via regulation of tyrosinase expression》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:56621-48-8).
5,6,7,8-Tetrahydro-4H-cyclohepta[d]isoxazole derivatives were synthesized and evaluated as a novel class of inhibitors for α-MSH (α-MSH) induced melanogenesis in a mouse melanoma B16F10 cell line. Three of the compounds (IC50 = 0.67 μM), (IC50 = 1.01 μM) and (IC50 = 0.99 μM) exhibited a potent inhibitory activity approx. 85- to 126-fold greater than kojic acid, a well-known potent inhibitor. A biochem. study indicates that the activity of this series should be displayed via down-regulation of the expression of tyrosinase.
In addition to the literature in the link below, there is a lot of literature about this compound(4-(Piperazin-1-yl)phenol)Product Details of 56621-48-8, illustrating the importance and wide applicability of this compound(56621-48-8).
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem