So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bhandare, Richie R.; Canney, Daniel J. researched the compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ).Computed Properties of C10H14N2O.They published the article 《Modifications to five-substituted 3,3-diethyl-4,5-dihydro-2(3H)-furanones en route to novel muscarinic receptor ligands》 about this compound( cas:56621-48-8 ) in Medicinal Chemistry Research. Keywords: ethyldihydrofuranone preparation; iodomethyllactone secondary amine amination hydroxymethyllactone piperidylbenzenisocyanate condensation; muscarinic receptor binding structure activity. We’ll tell you more about this compound (cas:56621-48-8).
Lead lactone-based ligands with modest affinity for muscarinic receptors were modified based on structure-activity relationship data in the literature to provide a new series of 5-substituted 4,5-dihydro-2(3H)-furanones. The modifications included the addition of various nitrogen-containing heterocycles attached to substituted and unsubstituted aromatic rings. The target compounds, e.g. I, were synthesized in modest yields and evaluated in preliminary muscarinic binding assays. A lactone-based ligand containing a diphenylmethylpiperazine moiety was identified as a nonselective muscarinic ligand with IC50 of 340 nM. The design of future ligands will be based, in part, on structure-activity data reported herein.
In addition to the literature in the link below, there is a lot of literature about this compound(4-(Piperazin-1-yl)phenol)Computed Properties of C10H14N2O, illustrating the importance and wide applicability of this compound(56621-48-8).
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem