In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Quantitative structure-hepatotoxicity assessment of series arylpiperazine-N1-substituted theobromine derivatives, published in 2020-02-29, which mentions a compound: 56621-48-8, mainly applied to arylpiperazinylalkyl theobromine preparation hepatotoxicity, Category: ethers-buliding-blocks.
In this work series new theobromines, compounds I [R = benzyl, 4-hydroxyphenyl, bis(4-fluorophenyl)methyl, etc.; n = 3,4] with established antioxidant and antiproliferative activities were evaluated for their hepatotoxic effects on cellular and sub-cellular level. On isolated rat hepatocytes, compounds I [R = 4-hydroxyphenyl, n = 3,4] expressed lowest toxicity, while compounds I [R = bis(4-fluorophenyl)methyl, n = 3,4] showed highest toxicity. Compounds I [R = bis(4-fluorophenyl)methyl, n = 3,4] showed the most evident pro-oxidant effect in a lipid peroxidation model on rat liver microsomes, followed by compounds I [R = 4-fluorophenyl, n = 3,4], while the other compounds didn’t reveal statistically significant pro-oxidant effects. The performed quant. structure-toxicity relationship (QSTR) anal. show that increased lipophilicity of the tested compounds pos. correlates to their hepatotoxicity. Opposite, the presence in the structure of highly pos. H-atoms and strongly neg. oxygen, possibly originating from hydrogen bond donor groups, are associated with reduced hepatotoxicity.
In addition to the literature in the link below, there is a lot of literature about this compound(4-(Piperazin-1-yl)phenol)Category: ethers-buliding-blocks, illustrating the importance and wide applicability of this compound(56621-48-8).
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem