Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 73590-85-9, is researched, Molecular C17H19N3O2S, about Stability-indicating methods for determining omeprazole and octylonium bromide in the presence of their degradation products, the main research direction is stability spectrophotometry omeprazole octylonium bromide determination; degradation omeprazole octylonium bromide determination TLC; densitometry degradation omeprazole octylonium bromide determination; chromatog densitometry degradation omeprazole octylonium bromide determination.SDS of cas: 73590-85-9.
Four stability-indicating assays were developed for determining omeprazole and octylonium bromide. Omeprazole was photodegraded and determined in the presence of its degradation products omeprazole sulfenimide and benzimidazole sulfide by 2 methods. The first method depends on use of first-, second-, and third-derivative spectrophotometry at 290.4, 320.6, and 311.6 nm, resp. The second method was based on applying the charge-transfer technique with chloranil as π acceptor to form a complex with omeprazole, the absorbance of which is measured at 377 nm. These methods determined omeprazole in concentration ranges of 5-20 μg/mL by first-, second-, and third-derivative spectrophotometry and 10-50 μg/mL by charge-transfer complexation with mean accuracies of 99.92, 99.71, 99.64, and 100.24%, resp. Octylonium bromide was determined by a TLC-densitometric method using in the presence of its degradation products p-[2-(n-octyoxy)benzoyl]aminobenzoic acid and diethyl-(2-hydroxyethyl)methylammonium bromide without any interferences. Alternatively, octylonium bromide was evaluated by a colorimetric method using the acid dye Rose Bengal. The ion pair formed was extracted in chloroform at pH 4, and its absorbance was measured at 562 nm. These methods determine octylonium bromide in the presence of its degradation products in concentration ranges of 0.1-0.5 μg/μL by densitometry and 4.5-22.5 μg/mL by colorimetry, with mean accuracies of 100.21 and 99.73%, resp. The suggested methods were used to determine drugs in bulk powder, laboratory-prepared mixtures, and pharmaceutical dosage forms. Results were compared statistically with those obtained with reference methods.
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