The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole( cas:73590-85-9 ) is researched.Category: ethers-buliding-blocks.Oelschlager, H.; Seeling, A.; Seeling, B.; Westesen, K.; Bunjes, H. published the article 《Selective oxidation of 5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methylthio]-1-H-benzimidazole to (RS-5-methoxy-2-[[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl]sulfinyl]-1-H-benzimidazole (omeprazole)》 about this compound( cas:73590-85-9 ) in Pharmazie. Keywords: omeprazole preparation decomposition kinetics; pyridylmethylthiobenzimidazole selective oxidation. Let’s learn more about this compound (cas:73590-85-9).
5-Methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methylthio]-1-H-benzimidazole was oxidized with Oxone in diluted EtOH at -5° furnishing omeprazole with an excellent yield. Addnl., decomposition kinetics of omeprazole in aqueous EtOH are presented.
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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem