So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lindberg, Per; Nordberg, Peter; Alminger, Tomas; Braendstroem, Arne; Wallmark, Bjoern researched the compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole( cas:73590-85-9 ).Application of 73590-85-9.They published the article 《The mechanism of action of the antisecretory agent omeprazole》 about this compound( cas:73590-85-9 ) in Journal of Medicinal Chemistry. Keywords: omeprazole active metabolite acid decomposition product; sulfenamide omeprazole active metabolite; stomach acid secretion omeprazole. We’ll tell you more about this compound (cas:73590-85-9).
The very potent gastric antisecretory agent omeprazole (I) [73590-58-6], presently under clin. evaluation, has been shown to act via inhibition of the gastric H+, K+-ATPase, the enzyme responsible for pumping of protons into the stomach. I needs acid activation to become an active inhibitor. A tetracyclic sulfenamide (II) was isolated from the acid decomposition of I. This sulfenamide, or, alternatively, the corresponding sulfenic acid, an unstable, probable intermediate in the sulfenamide formation, is the active inhibitor formed in vivo from omeprazole.
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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem