Franc, Gregory; Turrin, Cedric-Olivier; Cavero, Emma; Costes, Jean-Pierre; Duhayon, Carine; Caminade, Anne-Marie; Majoral, Jean-Pierre published the article 《gem-Bisphosphonate-Ended Group Dendrimers: Design and Gadolinium Complexing Properties》. Keywords: gem bisphosphonate terminated dendrimer gadolinium complex magnetic property; piperazino gem bisphosphonate functionalized gadolinium complex crystal structure.They researched the compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ).Category: ethers-buliding-blocks. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:56621-48-8) here.
The synthesis of the first gem-bisphosphonate-ended group dendrimers is described using nucleophilic substitution of terminal P(S)Cl2 units of phosphorus dendrimers of generation 1 to 3 with protected aminophenols followed by deprotection of amino groups and Michael addition with vinylidene tetraisopropyl bisphosphonate. These dendrimers were found to act as chelating agents towards Gd ions. Contrary to the phosphonic acids that can introduce bridges between Gd ions, these synthons act as unique chelating agents toward the Gd ions. Furthermore, it appears that the number of Gd ions introduced in the isolated units is equal to the number of gem-bisphosphonate pairs. Eventually, the magnetic measurements demonstrate clearly that the Gd ions are not coordinated to these pairs as isolated ions but that at least some of these ions are bridged through oxygen atoms that are not P=O functions, as shown by the structural determination given in the paper. Studies concerning properties of these Gd dendrimers complexes are under active study. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009).
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