The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole( cas:73590-85-9 ) is researched.COA of Formula: C17H19N3O2S.Nevado, Juan Jose Berzas; Penalvo, Gregorio Castaneda; Dorado, Rosa Maria Rodriguez; Robledo, Virginia Rodriguez published the article 《Simultaneous determination of omeprazole and their main metabolites in human urine samples by capillary electrophoresis using electrospray ionization-mass spectrometry detection》 about this compound( cas:73590-85-9 ) in Journal of Pharmaceutical and Biomedical Analysis. Keywords: omeprazole metabolite capillary electrophoresis electrospray ionization mass spectrometry; Capillary electrophoresis-mass spectrometry; Human urine; Metabolites; Omeprazole; Pharmacokinetics. Let’s learn more about this compound (cas:73590-85-9).
The authors report a novel method for the simultaneous determination of omeprazole and their main metabolites (omeprazole sulfide, omeprazole sulfone and 5-hydroxy omeprazole) in human urine samples. For this purpose, two new capillary electrophoresis (CE) methods were developed for the simultaneous determination of target compounds, using initially diode-array for optical detection and electrospray ionization-mass spectrometry (ESI-MS) for metabolites identification and identity confirmation. A new metabolite (5-hydroxysulfide omeprazole) was identified by electrospray ionization multi-stage mass spectrometry (ESI-MS2) fragment which was then used to support the proposed chem. structure. Pharmacokinetic results using CE method were compared with those obtained when a HPLC method was used. Equivalent pharmacokinetics profiles resulted when any anal. methods were carried out.
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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem