The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine(SMILESS: NC1=CC(C2=CC=CS2)=NN1C,cas:118430-78-7) is researched.COA of Formula: C17H19N3O2S. The article 《N,N-Dialkyl-N’-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. Part XII.* Synthesis and Reactivity of the Pyrazolo[3,4-e][1,2,4]thiadiazine Ring System》 in relation to this compound, is published in Australian Journal of Chemistry. Let’s take a look at the latest research on this compound (cas:118430-78-7).
N,N-Dialkyl-N’-chlorosulfonyl chloroformamidines 1 reacted regioselectively with 1-substituted 5-aminopyrazoles 2 via a 1,3-CCN dinucleophilic substitution to afford pyrazolo[3,4-e][1,2,4]thiadiazines 3 e. g., I, as the sole isolated products. Compounds 3, representatives of a very rare ring system, were shown to possess three nucleophilic sites at N2, N4, and N6. Methylation occurred at all three sites. Alkylation with benzylic halides occurred preferentially at N2, but some also occurred at N4, and at C7a. Alkylation with Et bromoacetate occurred at both N4 and N6, but the latter derivatives underwent a pyrazole ring expansion to afford pyrimido[4,5-e][1,2,4]thiadiazine derivs, e. g., II. Compounds 3 were unreactive towards various acylating agents.
Here is just a brief introduction to this compound(118430-78-7)COA of Formula: C8H9N3S, more information about the compound(1-Methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine) is in the article, you can click the link below.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem