In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Asymmetric synthesis of esomeprazole, published in 2000-09-22, which mentions a compound: 73590-85-9, mainly applied to esomeprazole asym synthesis, Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole.
A highly efficient synthesis of esomeprazole – the (S)-enantiomer of omeprazole – via asym. oxidation of prochiral sulfide I is described. The asym. oxidation was achieved by titanium-mediated oxidation with cumene hydroperoxide (CHP) in the presence of (S,S)-diethyl tartrate [(S,S)-DET]. The enantioselectivity was provided by preparing the titanium complex in the presence of I at an elevated temperature and/or during a prolonged preparation time and by performing the oxidation of I in the presence of an amine. An enantioselectivity of >94% ee was obtained using this method.
Compound(73590-85-9)Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole), if you are interested, you can check out my other related articles.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem