Application of 73590-85-9. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole, is researched, Molecular C17H19N3O2S, CAS is 73590-85-9, about A simple and sensitive bioanalytical assay for simultaneous determination of omeprazole and its three major metabolites in human blood plasma using RP-HPLC after a simple liquid-liquid extraction procedure. Author is Rezk, Naser L.; Brown, Kevin C.; Kashuba, Angela D. M..
A simple, sensitive and specific reverse-phase high-performance liquid chromatog. (HPLC) assay for the simultaneous quant. determination of omeprazole and its three metabolites in human plasma was developed and validated. This method provides excellent chromatog. resolution and peak shape for the four components and the internal standard within a 17 min run time. The simple extraction method results in a clean base line and relatively high extraction efficiency. The method was validated over the range of 2-2000 ng/mL, with 2.0 ng/mL as the lower limit of quantification. Within- and between-day accuracies for five different concentrations ranged from 95 to 102%, and 95 to 114%, resp. Within- and between-day precision ranged from 1.1 to 6.3% and 0.5 to 6.2%, resp. Simplicity and high throughput make this method suitable for clin. pharmacokinetic studies.
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