In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A novel class of ethacrynic acid derivatives as promising drug-like potent generation of anticancer agents with established mechanism of action, published in 2016-10-21, which mentions a compound: 56621-48-8, mainly applied to ethacrynate derivative preparation antitumor antiproliferative structure activity glutathione transferase; Anticancer agents; Ethacrynic acid; Ethacrynic acid derivatives; Glutathione S-Transferase π, Recommanded Product: 4-(Piperazin-1-yl)phenol.
The well-known diuretic Ethacrynic acid (EA, Edecrin), showing low anti-proliferative activities, was chem. modified at different positions. The new EA derivatives have been tested in vitro in anti-proliferative assays on both tumor KB (epidermal carcinoma) and leukemia HL60 (promyelocytic) cells suitable targets for anticancer activity. Reduction of the α-β double bond of EA completely abolished anti-cancer activities, whereas introduction of either 2-(4-substituted phenyl)ethanamine (series A) or 4-(4-substituted phenyl)piperazine (series B) moieties generated compounds showing moderate to strong anti-proliferative activities against human cancer cell lines. Several substitutions on the Ph of these two moieties are tolerated. The mechanism of action of the EA derivatives prepared in this study is more complex than the inhibition of glutathione S-transferase π ascribed as unique effect to EA and might help to overcome tumor resistances.
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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem