Month: April 2022

Category: ethers-buliding-blocks. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole, is researched, Molecular C17H19N3O2S, CAS is 73590-85-9, about Chirality in the limelight: Issue. Author is Federsel, Hans-Juergen.

A review. The author addresses the features of chiral mols., with special emphasis on current thinking about ways to produce them at scale. Two examples such as oxidation of pyrmetazole to omeprazole and suitability of (S)-Azetidine-2-carboxylic acid for scaling up are given.

The article 《Chirality in the limelight: Issue》 also mentions many details about this compound(73590-85-9)Category: ethers-buliding-blocks, you can pay attention to it, because details determine success or failure

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Electrochemical oxidation of acetaminophen and 4-(piperazin-1-yl)phenols in the presence of 4-hydroxy-1-methyl-2(1H)-quinolone, published in 2013, which mentions a compound: 56621-48-8, Name is 4-(Piperazin-1-yl)phenol, Molecular C10H14N2O, Recommanded Product: 56621-48-8.

A facile and 1-pot electrochem. method for the synthesis of mono and disubstituted 1,4-benzoquinones generated from the electrochem. oxidation of 1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone (1a), 4-(piperazin-1-yl)phenol (1b) and acetaminophen (8) in the presence of 4-hydroxy-1-methyl-2(1H)-quinolone (3) as nucleophile is reported. The electrochem. generated electrophiles derived from the oxidation of 1a, 1b and 8 participate in Michael-addition reactions with 3. The authors report the synthesis of mono and diquinolone substituted of 1,4-benzoquinone in good yields based on controlled potential condition at C electrode in a divided cell.

The article 《Electrochemical oxidation of acetaminophen and 4-(piperazin-1-yl)phenols in the presence of 4-hydroxy-1-methyl-2(1H)-quinolone》 also mentions many details about this compound(56621-48-8)Recommanded Product: 56621-48-8, you can pay attention to it, because details determine success or failure

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 56621-48-8, is researched, Molecular C10H14N2O, about Synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxypropyl]-pyrrolidin-2-one derivatives with anti-arrhythmic, hypotensive, and α-adrenolytic activity, the main research direction is piperazine pyrrolidinone preparation antiarrhythmic hypotensive adrenolytic SAR.Safety of 4-(Piperazin-1-yl)phenol.

A series of novel arylpiperazines bearing a pyrrolidin-2-one fragment was synthesized and evaluated for the binding affinity of the α1- and α2-adrenoceptors (AR) and for the antiarrhythmic and hypotensive activities of the compounds The most potent and selective compound 1-[2-hydroxy-3-[4-[(2-hydroxyphenyl)piperazin-1-yl]propyl]pyrrolidin-2-one 8 binds with pKi = 6.71 for α1-AR. Derivative 8 (I) was also the most active in the prophylactic antiarrhythmic test in adrenaline-induced arrhythmia in anesthetized rats. Its ED50 value equals 1.9 mg/kg (i.v.). Compounds with substituents such as a fluorine atom 4, a Me 5, or a hydroxyl 8 group, or two substituents such as fluorine/chlorine atoms and methoxy groups in the Ph ring, significantly decreased the systolic and diastolic pressure in normotensive anesthetized rats at a dosages of 5-10 mg/kg (i.v.). It was found that the presence of the piperazine ring and a hydroxy group in the second position of the Pr chain are critical structural features in determining the affinity of the compounds tested.

The article 《Synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxypropyl]-pyrrolidin-2-one derivatives with anti-arrhythmic, hypotensive, and α-adrenolytic activity》 also mentions many details about this compound(56621-48-8)Safety of 4-(Piperazin-1-yl)phenol, you can pay attention to it, because details determine success or failure

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 56621-48-8. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Thermodynamic study of the electrochemical oxidation of some aminophenol derivatives: Experimental and theoretical investigation. Author is Beiginejad, Hadi; Amani, Ameneh; Nematollahi, Davood; Khazalpour, Sadegh.

Electrochem. oxidation of some aminophenol derivatives (1-5) was studied both exptl. and theor. Exptl. results were obtained using cyclic voltammetry and controlled potential coulometry. The theor. results were calculated at DFT (B3LYP and BP86) levels of theory and 6-311 + G (p,d) basis sets. Using a general thermodn. cycle, the calculated ΔGtot of the oxidation of the studied aminophenol derivatives indicates that thermodn. is one of the important parameters on the potential oxidation Electrochem. oxidation potential of 1-5 is directly dependent on the ΔGtot of electrochem. oxidation In addition mechanisms of the electrochem. oxidation of 4-(piperazin-1-yl) phenol (6) in the presence of various nucleophiles was studied in viewpoint of the thermodn. Mechanistic study of the electrochem. oxidation of 6 in the presence of different nucleophiles indicates that although the electrochem. oxidations of 6H+ in the presence of different nucleophiles have different mechanisms but proceed in the thermodynamically favored directions.

The article 《Thermodynamic study of the electrochemical oxidation of some aminophenol derivatives: Experimental and theoretical investigation》 also mentions many details about this compound(56621-48-8)Recommanded Product: 56621-48-8, you can pay attention to it, because details determine success or failure

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Parsons, Andrew F. published the article 《A blockbuster synthesis for undergraduates》. Keywords: undergraduate education esomeprazole laboratory synthesis.They researched the compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole( cas:73590-85-9 ).Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:73590-85-9) here.

A context-based practical designed to give students the opportunity to improve their team working, communication and time-management skills was developed. By investigating the synthesis of the major antiulcer drug, esomeprazole, undergraduates are given an insight into the challenges of modern process chem., from optimization of the lead compound to its full-scale manufacture Students work as a team to prepare pyrmetazole from pyrmethyl alc. and then investigate the reaction conditions required to optimize the asym. oxidation of the sulfide group in pyrmetazole to form esomeprazole. Students do a series of small-scale oxidation reactions, using reagents and reaction conditions of their choice, to investigate how the conditions affect the efficiency of the oxidation They are required to plan their experiments to maximize the number of results they achieve over the eight-day period of the project and then provide a summary of their results and describe aspects of scaling-up their optimized reaction in individual reports, which are assessed. Their results are reviewed and compared with the current industrial process.

The article 《A blockbuster synthesis for undergraduates》 also mentions many details about this compound(73590-85-9)Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole, you can pay attention to it, because details determine success or failure

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ochiai, Hiroshi; Ishida, Akiharu; Ohtani, Tazumi; Kusumi, Kensuke; Kishikawa, Katuya; Yamamoto, Susumu; Takeda, Hiroshi; Obata, Takaaki; Nakai, Hisao; Toda, Masaaki published the article 《Discovery of new orally active phosphodiesterase (PDE4) inhibitors》. Keywords: phosphodiesterase PDE4 inhibitor discovery oral antiinflammatory; anilinopyrazolopyridine derivative preparation PDE4 inhibiting structure subtype selectivity.They researched the compound: 1-Methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine( cas:118430-78-7 ).Product Details of 118430-78-7. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:118430-78-7) here.

A series of 4-anilinopyrazolopyridine derivatives were synthesized and biol. evaluated as inhibitors of phosphodiesterase (PDE4). Chem. modification of 3, a structurally new chem. lead that was found in our inhouse library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chem. lead 5 are presented. Structure-activity relationship data, pharmacol. evaluation, and the subtype selectivity study are also presented.

The article 《Discovery of new orally active phosphodiesterase (PDE4) inhibitors》 also mentions many details about this compound(118430-78-7)Product Details of 118430-78-7, you can pay attention to it, because details determine success or failure

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 4-(Piperazin-1-yl)phenol. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Modifications to five-substituted 3,3-diethyl-4,5-dihydro-2(3H)-furanones en route to novel muscarinic receptor ligands. Author is Bhandare, Richie R.; Canney, Daniel J..

Lead lactone-based ligands with modest affinity for muscarinic receptors were modified based on structure-activity relationship data in the literature to provide a new series of 5-substituted 4,5-dihydro-2(3H)-furanones. The modifications included the addition of various nitrogen-containing heterocycles attached to substituted and unsubstituted aromatic rings. The target compounds, e.g. I, were synthesized in modest yields and evaluated in preliminary muscarinic binding assays. A lactone-based ligand containing a diphenylmethylpiperazine moiety was identified as a nonselective muscarinic ligand with IC50 of 340 nM. The design of future ligands will be based, in part, on structure-activity data reported herein.

The article 《Modifications to five-substituted 3,3-diethyl-4,5-dihydro-2(3H)-furanones en route to novel muscarinic receptor ligands》 also mentions many details about this compound(56621-48-8)Recommanded Product: 4-(Piperazin-1-yl)phenol, you can pay attention to it, because details determine success or failure

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 56621-48-8, is researched, SMILESS is OC1=CC=C(N2CCNCC2)C=C1, Molecular C10H14N2OJournal, Asian Journal of Chemistry called Synthesis and characterization of 3-substituted indole derivatives as novel Mannich bases, Author is Erdag, E., the main research direction is piperazinyl methyl indole preparation; indole piperazine formalin Mannich microwave irradiation.Synthetic Route of C10H14N2O.

In this study, indole-based 4-substituted piperazine derivatives I [R = Me, 4-BrC6H4, 4-HOC6H4, 4-F3C6H4, etc.] were synthesized via Mannich reaction with microwave assisted synthesis and the conventional reflux heating method. Microwave assisted synthesis was more preferable than reflux method since the microwave irradiation lead to a higher product yields with better purity and improved energy efficiency with shortened reaction time. The structures of 3-substituted indole derivatives I were characterized by FT-IR, elemental anal., 1H NMR and 13C NMR spectroscopy.

The article 《Synthesis and characterization of 3-substituted indole derivatives as novel Mannich bases》 also mentions many details about this compound(56621-48-8)Synthetic Route of C10H14N2O, you can pay attention to it, because details determine success or failure

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C17H19N3O2S. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole, is researched, Molecular C17H19N3O2S, CAS is 73590-85-9, about 13C Satellite-Free 1H NMR Spectra. Author is Moutzouri, Pinelopi; Kiraly, Peter; Phillips, Andrew R.; Coombes, Steven R.; Nilsson, Mathias; Morris, Gareth A..

A new NMR experiment (Destruction of Interfering Satellites by Perfect Echo Low-pass filtration, DISPEL) is introduced that facilitates the anal. of low-level components in high dynamic range mixtures by suppressing one-bond 13C satellite signals in 1H spectra. Since the natural abundance of 13C is around 1.1%, these satellites appear at 0.54% of the intensity of a parent peak, mimicking and often masking impurity signals. The new experiment suppresses one-bond 13C satellite signals, with high efficiency, at negligible cost in signal-to-noise ratio, and over a wide range of one-bond coupling constants, without the need for broadband 13C decoupling.

The article 《13C Satellite-Free 1H NMR Spectra》 also mentions many details about this compound(73590-85-9)Synthetic Route of C17H19N3O2S, you can pay attention to it, because details determine success or failure

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 56621-48-8, is researched, SMILESS is OC1=CC=C(N2CCNCC2)C=C1, Molecular C10H14N2OJournal, Article, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1-XPF, Author is Elmenoufy, Ahmed H.; Gentile, Francesco; Jay, David; Karimi-Busheri, Feridoun; Yang, Xiaoyan; Soueidan, Olivier M.; Weilbeer, Claudia; Mani, Rajam S.; Barakat, Khaled H.; Tuszynski, Jack A.; Weinfeld, Michael; West, Frederick G., the main research direction is ERCC1 XPF DNA repair inhibition neoplasm antitumor.Application In Synthesis of 4-(Piperazin-1-yl)phenol.

The ERCC1-XPF heterodimer is a 5′-3′ structure-specific endonuclease, which plays an essential role in several DNA repair pathways in mammalian cells. ERCC1-XPF is primarily involved in the repair of chem. induced helix-distorting and bulky DNA lesions, such as cyclobutane pyrimidine dimers (CPDs), and DNA interstrand cross-links. Inhibition of ERCC1-XPF has been shown to potentiate cytotoxicity of platinum-based drugs and cyclophosphamide in cancer cells. In this study, the previously described ERCC1-XPF inhibitor 4-((6-chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol (compound 1) was used as a reference compound Following the outcome of docking-based virtual screening (VS), we synthesized seven novel derivatives of 1 that were identified in silico as being likely to have high binding affinity for the ERCC1-XPF heterodimerization interface by interacting with the XPF double helix-hairpin-helix (HhH2) domain. Two of the new compounds, 4-((6-chloro-2-methoxyacridin-9-yl)amino)-2-((4-cyclohexylpiperazin-1-yl)methyl)phenol (compound 3) and 4-((6-chloro-2-methoxyacridin-9-yl)amino)-2-((4-(2-(dimethylamino)ethyl) piperazin-1-yl) methyl) phenol (compound 4), were shown to be potent inhibitors of ERCC1-XPF activity in vitro. Compound 4 showed significant inhibition of the removal of CPDs in UV-irradiated cells and the capacity to sensitize colorectal cancer cells to UV radiation and cyclophosphamide.

The article 《Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1-XPF》 also mentions many details about this compound(56621-48-8)Application In Synthesis of 4-(Piperazin-1-yl)phenol, you can pay attention to it, because details determine success or failure

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem