Kondeva-Burdina, Magdalena; Valkova, Iva; Andonova, Lily; Georgieva, Maya; Tzankova, Virginia; Zlatkov, Alexander published the article 《Quantitative structure-hepatotoxicity assessment of series arylpiperazine-N1-substituted theobromine derivatives》. Keywords: arylpiperazinylalkyl theobromine preparation hepatotoxicity.They researched the compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ).Synthetic Route of C10H14N2O. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:56621-48-8) here.
In this work series new theobromines, compounds I [R = benzyl, 4-hydroxyphenyl, bis(4-fluorophenyl)methyl, etc.; n = 3,4] with established antioxidant and antiproliferative activities were evaluated for their hepatotoxic effects on cellular and sub-cellular level. On isolated rat hepatocytes, compounds I [R = 4-hydroxyphenyl, n = 3,4] expressed lowest toxicity, while compounds I [R = bis(4-fluorophenyl)methyl, n = 3,4] showed highest toxicity. Compounds I [R = bis(4-fluorophenyl)methyl, n = 3,4] showed the most evident pro-oxidant effect in a lipid peroxidation model on rat liver microsomes, followed by compounds I [R = 4-fluorophenyl, n = 3,4], while the other compounds didn’t reveal statistically significant pro-oxidant effects. The performed quant. structure-toxicity relationship (QSTR) anal. show that increased lipophilicity of the tested compounds pos. correlates to their hepatotoxicity. Opposite, the presence in the structure of highly pos. H-atoms and strongly neg. oxygen, possibly originating from hydrogen bond donor groups, are associated with reduced hepatotoxicity.
There is still a lot of research devoted to this compound(SMILES：OC1=CC=C(N2CCNCC2)C=C1)Synthetic Route of C10H14N2O, and with the development of science, more effects of this compound(56621-48-8) can be discovered.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem