Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Chromatography, Biomedical Applications called High-performance liquid chromatographic assay for human liver microsomal omeprazole metabolism, Author is Andersson, Tommy; Lagerstroem, Per Olof; Miners, John O.; Veronese, Maurice E.; Weidorf, Lars; Birkett, Donald J., which mentions a compound: 73590-85-9, SMILESS is CC1=CN=C(CSC2=NC3=CC(OC)=CC=C3N2)C(C)=C1OC, Molecular C17H19N3O2S, HPLC of Formula: 73590-85-9.
Assays for the measurement of omeprazole metabolites in plasma and urine were reported, but when applied to the determination of omeprazole metabolites formed by human liver microsomal incubations, there were obvious limitations in sensitivity. The present HPLC assay, which comprises extraction, evaporation and reconstitution, is several-fold more sensitive with a limit of detection of ∼ 2 pmol (2 nM in incubate) for omeprazole sulfone and 25 pmol (25 nM in incubate) for hydroxyomeprazole. Extraction efficiency is essentially quant. and is highly reproducible (coefficient of variation = 2.1% for both metabolites). The assay is linear over a wide range of concentrations and the formation of the metabolites is linear with respect to both time (to 15 min) and protein concentration (to 1.5 mg/mL). Two minor metabolites, 1 of which was identified tentatively as 5-O-desmethylomeprazole, were also formed by human liver microsomes and could be determined by this method. Preliminary studies of the formation of omeprazole sulfone and hydroxyomeprazole showed that the formation kinetics in human liver microsomes were biphasic for both metabolites, suggesting that at least 2 different cytochrome P 450 isoforms are involved in their formation.
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