In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called SuFEx-enabled, chemoselective synthesis of triflates, triflamides and triflimidates, published in 2022, which mentions a compound: 56621-48-8, mainly applied to aryltriflate preparation; aryltriflamide preparation; aryltriflimidate preparation; aryl amide preparation, Recommanded Product: 4-(Piperazin-1-yl)phenol.
The ex-situ generation of trifluoromethanesulfonyl fluoride (CF3SO2F) gas in a two chamber system, and its use as a new SuFEx handle to efficiently synthesize triflates and triflamides were reported. This broadly tolerated protocol lends itself to peptide modification or to telescoping into coupling reactions. Moreover, redesigning the SVI-F connector with a S=O → S=NR replacement furnished the analogous triflimidoyl fluorides as SuFEx electrophiles, which were engaged in the synthesis of rarely reported triflimidate esters. Notably, experiments showed H2O to be the key towards achieving chemoselective trifluoromethanesulfonation of phenols vs. amine groups, a phenomenon best explained-using ab initio metadynamics simulations-by a hydrogen bonded termol. transition state for the CF3SO2F triflylation of amines.
Here is a brief introduction to this compound(56621-48-8)Recommanded Product: 4-(Piperazin-1-yl)phenol, if you want to know about other compounds related to this compound(56621-48-8), you can read my other articles.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem