Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 56621-48-8, is researched, SMILESS is OC1=CC=C(N2CCNCC2)C=C1, Molecular C10H14N2OJournal, Article, Research Support, Non-U.S. Gov’t, Bioorganic & Medicinal Chemistry called Discovery of a new potent inhibitor of mushroom tyrosinase (Agaricus bisporus) containing 4-(4-hydroxyphenyl)piperazin-1-yl moiety, Author is De Luca, Laura; Germano, Maria Paola; Fais, Antonella; Pintus, Francesca; Buemi, Maria Rosa; Vittorio, Serena; Mirabile, Salvatore; Rapisarda, Antonio; Gitto, Rosaria, the main research direction is hydroxyphenyl piperazinyl derivative preparation mushroom tyrosinase inhibitor antioxidant; Agaricus Bisporus; Docking studies; Hela cells; Phenylpiperazines; Tyrosinase inhibitors.Application of 56621-48-8.
Tyrosinase (TYR, EC 1.14.18.1) plays a pivotal role in mammalian melanogenesis and enzymic browning of plant-derived food. Therefore, tyrosinase inhibitors (TYRIs) can be of interest in cosmetics and pharmaceutical industries as depigmentation compounds as well as anti-browning agents. Starting from 4-benzylpiperidine derivatives that showed good inhibitory properties toward tyrosinase from Agaricus bisporus (TyM), we synthesized a new series of TYRIs named 3-(4-benzyl-1-piperidyl)-1-(4-phenylpiperazin-1-yl)propan-1-one and 2-(4-benzyl-1-piperidyl)-1-(4-phenylpiperazin-1-yl)ethanone derivatives Among them, compound 4b proved to be the most potent inhibitor (IC50 = 3.80μM) and it also showed a good antioxidant activity. These new data furnished addnl. information about the SAR for this class of TYRIs.
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