An article Integrating Exposure Knowledge and Serum Suspect Screening as a New Approach to Biomonitoring: An Application in Firefighters and Office Workers WOS:000526418000066 published article about POLYCYCLIC AROMATIC-HYDROCARBONS; FLORIDA PROFESSIONAL FIREFIGHTERS; OCCUPATIONAL-EXPOSURE; CANCER INCIDENCE; FLAME RETARDANTS; US FIREFIGHTERS; SAN-FRANCISCO; RISK; CALIFORNIA; EXPOSOME in [Grashow, Rachel; Bessonneau, Vincent; Rudel, Ruthann A.] Silent Spring Inst, Newton, MA 02460 USA; [Trowbridge, Jessica; Morello-Frosch, Rachel] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA; [Morello-Frosch, Rachel] Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA; [Gerona, Roy; Lin, Thomas] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, Clin Toxicol & Environm Biomonitoring Lab, San Francisco, CA 94143 USA; [Wang, Aolin] Univ Calif San Francisco, Program Reprod Hlth & Environm, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA; [Wang, Aolin] Univ Calif San Francisco, Bakar Computat Hlth Sci Inst, San Francisco, CA 94143 USA; [Buren, Heather] United Fire Serv Women, San Francisco, CA 94143 USA in 2020.0, Cited 60.0. The Name is Diphenyl oxide. Through research, I have a further understanding and discovery of 101-84-8. SDS of cas: 101-84-8
Firefighters (FF) are exposed to recognized and probable carcinogens, yet there are few studies of chemical exposures and associated health concerns in women FFs, such as breast cancer. Biomonitoring often requires a priori selection of compounds to be measured, and so, it may not detect relevant, lesser known, exposures. The Women FFs Biomonitoring Collaborative (WFBC) created a biological sample archive and conducted a general suspect screen (GSS) to address this data gap. Using liquid chromatography-quadrupole time-of-flight tandem mass spectrometry, we sought to identify candidate chemicals of interest in serum samples from 83 women FFs and 79 women office workers (OW) in San Francisco. We identified chemical peaks by matching accurate mass from serum samples against a custom chemical database of 722 slightly polar phenolic and acidic compounds, including many of relevance to firefighting or breast cancer etiology. We then selected tentatively identified chemicals for confirmation based on the following criteria: (1) detection frequency or peak area differences between OW and FF; (2) evidence of mammary carcinogenicity, estrogenicity, or genotoxicity; and (3) not currently measured in large biomonitoring studies. We detected 620 chemicals that matched 300 molecular formulas in the WFBC database, including phthalate metabolites, phosphate flame-retardant metabolites, phenols, pesticides, nitro and nitroso compounds, and per- and polyfluoroalkyl substances. Of the 20 suspect chemicals selected for validation, 8 were confirmed-including two alkylphenols, ethyl paraben, BPF, PFOSAA, benzophenone-3, benzyl p-hydroxybenzoate, and triphenyl phosphate-by running a matrix spike of the reference standards and using m/z, retention time, and the confirmation of at least two fragment ions as criteria for matching. GSS provides a powerful highthroughput approach to identify and prioritize novel chemicals for biomonitoring and health studies.
Welcome to talk about 101-84-8, If you have any questions, you can contact Grashow, R; Bessonneau, V; Gerona, R; Wang, A; Trowbridge, J; Lin, T; Buren, H; Rudel, RA; Morello-Frosch, R or send Email.. SDS of cas: 101-84-8
Reference:
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