Deng, ZJ; Zhao, MX; Wang, F; Tang, PP in [Deng, Zhijie; Zhao, Mingxin; Wang, Feng; Tang, Pingping] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China; [Deng, Zhijie; Zhao, Mingxin; Wang, Feng; Tang, Pingping] Nankai Univ, Coll Chem, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China published Selective C-H trifluoromethoxylation of (hetero)arenes as limiting reagent in 2020.0, Cited 67.0. Formula: C12H10O. The Name is Diphenyl oxide. Through research, I have a further understanding and discovery of 101-84-8.
Methods for direct C-H trifluoromethoxylation of arenes and heteroarenes are rare, despite the importance of trifluoromethoxylated compounds for pharmaceuticals, agrochemicals, and material sciences. Especially selective C-H trifluoromethoxylation of pyridines remains a formidable challenge. Here we show a general late-stage C-H trifluoromethoxylation of arenes and heteroarenes as limiting reagent with trifluoromethoxide anion. The reaction is mediated by silver salts under mild reaction conditions, exhibiting broad substrate scope and wide functional-group compatibility. In addition, ortho-position selective C-H trifluoromethoxylation of pyridines is observed. The method is not only applicable to the gram-scale synthesis of trifluoromethoxylated products but also allows efficient late-stage C-H trifluoromethoxylation of marketed small-molecule drugs, common pharmacophores and natural products. Selective C-H trifluoromethoxylation of pyridines remains a formidable synthetic challenge. Here, the authors report a silver-mediated late-stage C-H trifluoromethoxylation of arenes and heteroarenes as limiting reagents with trifluoromethoxide anion.
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Reference:
Ether – Wikipedia,
,Ether | (C2H5)2O – PubChem