I found the field of Biotechnology & Applied Microbiology; Science & Technology – Other Topics very interesting. Saw the article DMSA-coated cubic iron oxide nanoparticles as potential therapeutic agents published in 2021. Name: Benzyl ether, Reprint Addresses Thanh, NTK (corresponding author), Royal Inst Great Britain, UCL Healthcare Biomagnet & Nanomat Labs, 21 Albemarle St, London W1S 4BS, England.; Thanh, NTK (corresponding author), UCL, Dept Phys & Astron, Biophys Grp, Gower St, London WC1E 6BT, England.. The CAS is 103-50-4. Through research, I have a further understanding and discovery of Benzyl ether
Aim: Superparamagnetic cubic iron oxide nanoparticles (IONPs) were synthesized and functionalized with meso-2,3-dimercaptosuccinic acid (DMSA) as a potential agent for cancer treatment. Methods: Monodisperse cubic IONPs with a high value of saturation magnetization were synthesized by thermal decomposition method and functionalized with DMSA via ligand exchange reaction, and their cytotoxic effects on HeLa cells were investigated. Results: DMSA functionalized cubic IONPs with an edge length of 24.5 +/- 1.9 nm had a specific absorption rate value of 197.4 W/g(Fe) (15.95 kA/m and 488 kHz) and showed slight cytotoxicity on HeLa cells when incubated with 3.3 x 10(10), 6.6 x 10(10) and 9.9 x 10(10) NP/mL for 24, 48 and 72 h. Conclusion: To the best of our knowledge, this is the first study to investigate both the cytotoxic effects of DMSA-coated cubic IONPs on HeLa cells and hyperthermia performance of these nanoparticles.
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Reference:
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