Quality Control of Benzyl ether. I found the field of Chemistry; Engineering; Pharmacology & Pharmacy very interesting. Saw the article Synthesis, purification, and anticancer effect of magnetic Fe3O4-loaded poly (lactic-co-glycolic) nanoparticles of the natural drug tetrandrine published in 2019, Reprint Addresses Shi, C (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, 1277 Jiefang Ave, Wuhan 430022, Hubei, Peoples R China.. The CAS is 103-50-4. Through research, I have a further understanding and discovery of Benzyl ether.
Here, we have successfully synthesised and purified multifunctional PLGA-based nanoparticles by the co-encapsulation of an anticancer drug (tetrandrine) and a magnetic material (Fe3O4). The obtained Tet-Fe3O4-PLGA NPs had a uniform spherical shape with a particle size of approximately 199nm and a negative surface charge of -18.0mV, displaying a high encapsulation efficiency. Furthermore, TEM studies provided representative images of the purification process of the magnetic nanoparticles with MACS((R)) technology. The MFM and VSM results indicated that both the Fe3O4 NPs and Tet-Fe3O4-PLGA NPs were superparamagnetic. The DSC spectrum demonstrated that Tet was successfully encapsulated within the PLGA-based nanoparticles. Significantly, the release studies revealed NPs had a relatively slower release rate than free Tet after 8h’s initial burst release, which had decreased from 98% to 65% after 24h. In vitro cellular studies revealed that NPs could effectively penetrate into A549 cells and A549 multicellular spheroids to exert cytotoxicity, displaying a significantly high anti-proliferation effect. Moreover, western blot demonstrated that the co-loaded NPs had a higher anticancer activity by injuring lysosomes to activate the mitochondria pathway and induce A549 cell apoptosis. The magnetic characteristics and high anticancer activity support the use of Tet/Fe3O4 co-loaded PLGA-based nanoparticles as a promising strategy in the treatment of lung cancer.
Quality Control of Benzyl ether. Bye, fridends, I hope you can learn more about C14H14O, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Ether – Wikipedia,
,Ether | (C2H5)2O – PubChem