Recently I am researching about PHOTOTHERMAL THERAPY; PHOTOSENSITIZER; E6; MICELLES; E(6); EFFICACY, Saw an article supported by the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [R01CA181429, R01NS100892, R01CA175480, P01CA087971, P30CA016520, R01CA085831]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Cancer Institute (NCI) [R01CA175480, R01CA085831, R01CA181429, P01CA087971, P30CA016520] Funding Source: NIH RePORTER. Published in NATURE PUBLISHING GROUP in LONDON ,Authors: Amirshaghaghi, A; Yan, L; Miller, J; Daniel, Y; Stein, JM; Busch, TM; Cheng, ZL; Tsourkas, A. The CAS is 103-50-4. Through research, I have a further understanding and discovery of Benzyl ether. HPLC of Formula: C14H14O
Photodynamic therapy (PDT) is an approved modality for the treatment of various types of maligancies and diseased states. However, most of the available photosensitizers (PS) are highly hydrophobic, which limits their solubility and dispersion in biological fluids and can lead to self-quenching and sub-optimal therapeutic efficacy. In this study, chlorin e6 (Ce6)-coated superparamagnetic iron oxide nanoparticle (SPION) nanoclusters (Ce6-SCs) were prepared via an oil-in-water emulsion. The physical chemical properties of the Ce6-SCs were systematically evaluated. Dual-mode imaging and PDT was subsequently performed in tumor-bearing mice. Chlorin e6 is capable of solubilizing hydrophobic SPION into stable, water-soluble nanoclusters without the use of any additional amphiphiles or carriers. The method is reproducible and the Ce6-SCs are highly stable under physiological conditions. The Ce6-SCs have an average diameter of 92 nm and low polydispersity (average PDI < 0.2). Encapsulation efficiency of both Ce6 and SPION is approximate to 100%, and the total Ce6 payload can be as high as 56% of the total weight (Ce6 + Fe). The Ce6-SCs localize within tumors via enhanced permeability and retention and are detectable by magnetic resonance (MR) and optical imaging. With PDT, Ce6-SCs demonstrate high singlet oxygen generation and produce a significant delay in tumor growth in mice. HPLC of Formula: C14H14O. About Benzyl ether, If you have any questions, you can contact Amirshaghaghi, A; Yan, L; Miller, J; Daniel, Y; Stein, JM; Busch, TM; Cheng, ZL; Tsourkas, A or concate me.
Reference:
Ether – Wikipedia,
,Ether | (C2H5)2O – PubChem