In 2021.0 MOLECULES published article about PREGNANE-X-RECEPTOR; BIOLOGICAL EVALUATION; BILE-ACID; TRANSCRIPTIONAL REGULATION; CONDENSATION; METABOLISM; AGONIST; TARGET; GENE; SAR in [Juang, Shin-Hun; Hsieh, Min-Tsang; Hsu, Pei-Ling; Chen, Ju-Ling; Liang, Fong-Pin; Kuo, Sheng-Chu] China Med Univ, Sch Pharm, Taichung 404, Taiwan; [Hsieh, Min-Tsang] China Med Univ Hosp, Chinese Med Res & Dev Ctr, 2 Yude Rd, Taichung 404, Taiwan; [Chen, Ju-Ling; Chou, Chen-Hsi; Wu, Tian-Shung; Hung, Hsin-Yi] Natl Cheng Kung Univ, Sch Pharm, Coll Med, Tainan 701, Taiwan; [Liu, Hui-Kang] Minist Hlth & Welf, Natl Res Inst Chinese Med, Taipei 112, Taiwan; [Chiu, Chen-Yuan; Liu, Shing-Hwa] Natl Taiwan Univ, Grad Inst Toxicol, Coll Med, Taipei 100, Taiwan in 2021.0, Cited 59.0. The Name is Diphenyl oxide. Through research, I have a further understanding and discovery of 101-84-8. Application In Synthesis of Diphenyl oxide
Constitutive androstane receptor (CAR) activation has found to ameliorate diabetes in animal models. However, no CAR agonists are available clinically. Therefore, a safe and effective CAR activator would be an alternative option. In this study, sixty courmarin derivatives either synthesized or purified from Artemisia capillaris were screened for CAR activation activity. Chemical modifications were on position 5,6,7,8 with mono-, di-, tri-, or tetra-substitutions. Among all the compounds subjected for in vitro CAR activation screening, 6,7-diprenoxycoumarin was the most effective and was selected for further preclinical studies. Chemical modification on the 6 position and unsaturated chains were generally beneficial. Electron-withdrawn groups as well as long unsaturated chains were hazardous to the activity. Mechanism of action studies showed that CAR activation of 6,7-diprenoxycoumarin might be through the inhibition of EGFR signaling and upregulating PP2Ac methylation. To sum up, modification mimicking natural occurring coumarins shed light on CAR studies and the established screening system provides a rapid method for the discovery and development of CAR activators. In addition, one CAR activator, scoparone, did showed anti-diabetes effect in db/db mice without elevation of insulin levels.
About Diphenyl oxide, If you have any questions, you can contact Juang, SH; Hsieh, MT; Hsu, PL; Chen, JL; Liu, HK; Liang, FP; Kuo, SC; Chiu, CY; Liu, SH; Chou, CH; Wu, TS; Hung, HY or concate me.. Application In Synthesis of Diphenyl oxide
Reference:
Ether – Wikipedia,
,Ether | (C2H5)2O – PubChem