An article Hepatic Transcriptomic Patterns in the Neonatal Rat After Pentabromodiphenyl Ether Exposure WOS:000502431900001 published article about POLYBROMINATED DIPHENYL ETHERS; THYROID-HORMONES; OXIDATIVE STRESS; PBDE EXPOSURE; LIVER-MICROSOMES; GENE-EXPRESSION; E-WASTE; METABOLISM; HEALTH; DISPOSITION in [Dunnick, June K.; Morgan, Daniel L.] NIEHS, Toxicol Branch, Div Natl Toxicol Program, POB 12233, Res Triangle Pk, NC 27709 USA; [Shockley, Keith R.] NIEHS, Biostat & Computat Biol Branch, Div Intramural Res Toxicol Program, POB 12233, Res Triangle Pk, NC 27709 USA; [Travlos, Gregory S.; Ton, Thai-Vu T.; Wilson, Ralph; Brar, Sukhdev S.; Pandiri, Arun Kumar R.] NIEHS, Cellular & Mol Pathol Branch, Div Natl Toxicol Program, POB 12233, Res Triangle Pk, NC 27709 USA; [Gerrish, Kevin] NIEHS, Mol Genom Core, Div Intramural Res, POB 12233, Res Triangle Pk, NC 27709 USA; [Brix, Amy E.] EPL Inc, Res Triangle Pk, NC USA; [Waidyanatha, Suramya; Mutlu, Esra] NIEHS, Program Operat Branch, Div Natl Toxicol Program, POB 12233, Res Triangle Pk, NC 27709 USA in 2020.0, Cited 84.0. COA of Formula: C12H10O. The Name is Diphenyl oxide. Through research, I have a further understanding and discovery of 101-84-8
Human exposure to pentabromodiphenyl ether (PBDE) mixture (DE-71) and its PBDE-47 congener can occur both in utero and during lactation. Here, we tested the hypothesis that PBDE-induced neonatal hepatic transcriptomic alterations in Wistar Han rat pups can inform on potential toxicity and carcinogenicity after longer term PBDE exposures. Wistar Han rat dams were exposed to either DE-71 or PBDE-47 daily from gestation day (GD 6) through postnatal day 4 (PND 4). Total plasma thyroxine (T4) was decreased in PND 4 pups. In liver, transcripts for CYPs and conjugation enzymes, Nrf2, and ABC transporters were upregulated. In general, the hepatic transcriptomic alterations after exposure to DE-71 or PBDE-47 were similar and provided early indicators of oxidative stress and metabolic alterations, key characteristics of toxicity processes. The transcriptional benchmark dose lower confidence limits of the most sensitive biological processes were lower for PBDE-47 than for the PBDE mixture. Neonatal rat liver transcriptomic data provide early indicators on molecular pathway alterations that may lead to toxicity and/or carcinogenicity if the exposures continue for longer durations. These early toxicogenomic indicators may be used to help prioritize chemicals for a more complete toxicity and cancer risk evaluation.
About Diphenyl oxide, If you have any questions, you can contact Dunnick, JK; Shockley, KR; Morgan, DL; Travlos, GS; Gerrish, K; Ton, TVT; Wilson, R; Brar, SS; Brix, AE; Waidyanatha, S; Mutlu, E; Pandiri, AKR or concate me.. COA of Formula: C12H10O
Reference:
Ether – Wikipedia,
,Ether | (C2H5)2O – PubChem