I found the field of Pharmacology & Pharmacy very interesting. Saw the article Discovery of Novel and Highly Potent Resorcinol Dibenzyl Ether-Based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment published in 2020. Recommanded Product: Benzyl ether, Reprint Addresses Chen, JJ (corresponding author), Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China.. The CAS is 103-50-4. Through research, I have a further understanding and discovery of Benzyl ether
A series of programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors based on the resorcinol diphenyl ether scaffold were discovered by incorporating hydrophilic moieties into the side chain and converting into the corresponding hydrochloride salt. Among these compounds, P18 showed the highest inhibitory activity against PD-1/PD-L1 with an IC50 value of 9.1 nM in a homogeneous time-resolved fluorescence binding assay. Besides, P18 promoted HepG2 cell death dose dependently in a HepG2/PD-L1 and Jurkat/PD-1 coculture cell model. Further, P18 demonstrated significantly higher water solubility (17.61 mg/mL) and improved pharmacokinetics (e.g., t(1/2) of similar to 20 h and oral bioavailability of 12%) than the previous analogues. Moreover, P18 was highly effective in suppressing tumor growth in an immune checkpoint humanized mouse model without apparent toxicity. Collectively, these results suggest that compound P18 represents a promising PD-1/PD-L1 inhibitor worthy of further investigation as a potential anticancer agent.
About Benzyl ether, If you have any questions, you can contact Cheng, BB; Wang, W; Niu, XG; Ren, YC; Liu, T; Cao, H; Wang, SH; Tu, YF; Chen, JX; Liu, SW; Yang, XC; Chen, JJ or concate me.. Recommanded Product: Benzyl ether
Reference:
Ether – Wikipedia,
,Ether | (C2H5)2O – PubChem