Electric Literature of 36865-41-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36865-41-5, name is 1-Bromo-3-methoxypropane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 5-bromo-2-methoxy-phenol (67.00 g, 330.00 mmol, 1.00 eq) and 1- bromo-3-methoxy-propane (100.99 g, 660.00 mmol, 2.00 eq) in DMF (300.00 mL) was added K2C03 (136.83 g, 990.00 mmol, 3.00 eq). The mixture was stirred at 25 C for 8 h. Desired product was observed on LC-MS. The reaction mixture was concentrated in vacuo and extracted with ethyl acetate (4OmL*3). The crude product was purified by flash column (Petroleum ether/Ethyl acetate=5/1) to give 4-bromo-1-methoxy-2-(3- methoxypropoxy)benzene (90.00 g, 327.11 mmol, 99.12 % yield) as a colorless oil. LC-MS:EW6 108-59-P 1Z (M+H=274.9, M+2+H=276.9)
The synthetic route of 1-Bromo-3-methoxypropane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NEWAVE PHARMACEUTICAL INC.; CHEN, Yi; (81 pag.)WO2018/22282; (2018); A1;,
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