Related Products of 627527-23-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 627527-23-5, name is 1-Bromo-3-methoxy-5-(trifluoromethyl)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step 2: Preparation of 8-[3-methoxy-5-(trifluoromethyl)phenyl]-1,4-dioxa-8- azaspiro[4.5]decane To a mixture of 1-bromo-3-methoxy-5-(trifluoromethyl)benzene (500 mg, 1.96 mmol), 1,4-dioxa-8-azaspiro[4.5]decane (281 mg, 1.96 mmol) and sodium tert-butoxide (377 mg, 3.92 mmol) in dioxane (10 mL) was added Pd2(dba)3 (71.8 mg, 78.4 mumol) and Ruphos (18.3 mg, 39.2 mumol) under N2. The resulting mixture was then heated with stirring at 100oC overnight. After being cooled down to rt, the resulting mixture was diluted with H2O (10 mL) and extracted with EA (30 mL) for three times. The organic layers were combined, dried over anhydrous Na2SO4 and concentrated in vacuo to give crude 8-(3-methoxy-5-(trifluoromethyl)phenyl)-1,4- dioxa-8-azaspiro[4.5]decane (650 mg) which was used in the next step directly without an further purification.
The synthetic route of 1-Bromo-3-methoxy-5-(trifluoromethyl)benzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; HAN, Xingchun; JIANG, Min; WANG, Jianhua; WANG, Min; WANG, Yongguang; YANG, Song; (319 pag.)WO2016/177655; (2016); A1;,
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