In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20781-20-8 as follows. Recommanded Product: (2,4-Dimethoxyphenyl)methanamine
To a solution of 2,4-dimethoxybenzylamine (Sigma-Aldrich) (6.6 mL, 43.5 mmol) in DCM (85 mL) was added saturated aqueous sodium bicarbonate solution (85 mL) and the mixture was stirred vigorously at RT for 15 min. Stirring was stopped; then thiophosgene (6.6 mL, 87 mmol) was added via syringe to the bottom layer. The mixture was stirred at RT for 90 min then the aqueous layer was separated and the organic layer was washed with brine, dried over Na2S04 and concentrated in vacuo twice from DCM to give l-(isothiocyanatomethyl)-2,4- dimethoxybenzene
According to the analysis of related databases, 20781-20-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KHAN, Tanweer; SMITH, Elizabeth; WILLIAMS, Peter; WISCOUNT, Catherine; MCKITTRICK, Brian; MCCAULEY, John; (72 pag.)WO2018/106519; (2018); A1;,
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