Related Products of 41365-75-7,Some common heterocyclic compound, 41365-75-7, name is 1-Amino-3,3-diethoxypropane, molecular formula is C7H17NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
a-5-1) 1-tert-Butoxycarbonylamino-3,3-diethoxypropane A mixture of di-tert-butyl dicarbonate (9 g, 40 mmol.) in dioxane (40 ml) is added drop by drop, with stirring and at 0 C., to a solution of 1-amino-3,3-diethoxypropane (5.52 g, 37 mmol) and Et3N (4.04 g, 40 mmol) in 5 ml dioxane. After 2 hrs, the mixture is stirred at ambient temperature for 12 hrs then the solvent is evaporated. The residual oil is taken up in 10 ml of water, acidified with 30 ml HCl (1%), then extracted with ethyl acetate (60 ml*3). The organic phases are dried (MgSO4) and evaporated to give 8.89 g of 1-tert-butoxycarbonylamino-3,3-diethoxypropane (90%). 1H NMR (CDCl3): 1.20 (t, 6H, J=8.8 Hz, CH3), 1.40 (s, 9H, C(CH3)3), 1.60-2.00 (m, 2H, CH2C), 3.00-3.80 (m, 6H, OCH2+NHCH2), 4.50 (t, 1H, J=6.4 Hz, CH), 5.05-5.10 (br, 1H, NH).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Amino-3,3-diethoxypropane, its application will become more common.
Reference:
Patent; Baudy Floc’h, Michele; Busnel, Olivier; Muller, Sylviane; US2011/44974; (2011); A1;,
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