In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16452-01-0, name is 3-Methoxy-4-methylaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 16452-01-0
Intermediate 18To a suspension of 4-methyl-3-(methyloxy)aniline (Intermediate 17, 1.86 g) in water (100 mL)/H2S04 (30 mL, 563 mmol) at 0C a solution of sodium nitrite (1.029 g, 14.91 mmol) in water (10 mL) was slowly added and the reaction mixture was stirred for 30 minutes at 0 C. The reaction mixture was slowly added to a solution of H2S04 98% (20 mL) in Water (80 mL) pre-heated at 90C and stirred at this temperature for 1 h. After cooling the mixture was extracted with Et20 (2x200mL), the organic layer was dried on sodium sulphate, filtered and evaporated to afford the title compound (1.86 g) as a red/brown oil.H-NMR (400 MHz, DMSO-c/6) delta ppm: 9.14 (1 H, br.s), 6.87 (1 H, d), 6.35 (1 H, d), 6.24 (1 H, dd), 3.71 (3H, s), 2.01 (3H, s); UPLC_B: 0.63 min, 137 [M-H]-.
The synthetic route of 16452-01-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; ALVARO, Giuseppe; DECOR, Anne; FONTANA, Stefano; HAMPRECHT, Dieter; LARGE, Charles; MARASCO, Agostino; WO2011/69951; (2011); A1;,
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