Synthetic Route of 16452-01-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16452-01-0, name is 3-Methoxy-4-methylaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 47 Part E. 4-Isothiocyanato-2-methoxy-1-methyl-benzene To a solution of 3-methoxy-4-methylaniline (50 mg, 0.36 mmol) in DCM (2 mL) was added thiocarbonyldiimizaole (68 mg, 0.38 mmol) and the mixture was stirred at rt for 3 h. The mixture was concentrated under reduced pressure, and the residue was dissolved in MeOH (3 mL) and filtered through an SCX cartridge (CUBX1HL, 500 mg cartridge, United Chemical Technologies, Bristol Pa., USA). The filtrate was concentrated under reduced pressure to afford the title compound which was used as such for the subsequent step without further purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methoxy-4-methylaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Bristol-Myers Squibb Company; US6596747; (2003); B2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem