Related Products of 20781-20-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20781-20-8 as follows.
A mixture of 2-chloropyrimidine (2.00 g, 17.50 mmol), (2,4-dimethoxyphenyl)methanamine (2.92 g, 17.50 mmol) and potassium carbonate (2.90 g, 21.00 mmol) in anhydrous acetonitrile (20 mL) was degassed with by sparging with nitrogen, and then stirred to 80 C. for 10 h. After cooling to ambient temperature, the reaction mixture was concentrated in vacuo. The residue was purified by column chromatography, eluting with 50% of petroleum ether in ethyl acetate, to afford the title compound as a yellow solid (2.10 g, 49% yield): 1H NMR (400 MHz, CDCl3) delta8.27 (d, J=4.5 Hz, 2H), 7.24 (d, J=8.3 Hz, 1H), 6.50 (t, J=4.8 Hz, 1H), 6.47 (d, J=2.5 Hz, 1H), 6.43 (dd, J=8.3, 2.5 Hz, 1H), 5.58 (br s, 1H), 4.55 (d, J=6.0 Hz, 2H), 3.83 (s, 3H), 3.80 (s, 3H).
According to the analysis of related databases, 20781-20-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Xenon Pharmaceuticals Inc.; Andrez, Jean-Christophe; Bogucki, David Earl; Burford, Kristen Nicole; Chowdhury, Sultan; Cohen, Charles Jay; Decker, Shannon Marie; Dehnhardt, Christoph Martin; Devita, Robert Joseph; Empfield, James Roy; Focken, Thilo; Grimwood, Michael Edward; Hasan, Syed Abid; Jia, Qi; Johnson, JR., James Philip; Wilson, Michael Scott; Zenova, Alla Yurevna; (287 pag.)US2018/162868; (2018); A1;,
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