Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 157869-15-3, name is 2-((4-Methoxyphenyl)ethynyl)aniline, A new synthetic method of this compound is introduced below., Product Details of 157869-15-3
In a 10 mL reactor, add 2-((4-methoxyphenyl) ethynyl) aniline (111.6 mg, 0.5 mmol), phenylacetone (80.5 mg, 0.6 mmol), Cu (OAc) 2 (9.1 mg, 0.05 mmol), 2,2′-bipyridine (15.6 mg, 0.1 mmol), 4-OH-TEMPO (86.1 mg, 0.5 mmol) and 3 mL 1,2-dichlorobenzene. After heating at 120 C for 24 hours, the solvent was concentrated under reduced pressure to recover the solvent, which was separated (n-hexane / ethyl acetate = 50/1, v / v) to obtain 3- (2- (4-methoxyphenyl) as a white solid -1H-indol-1-yl) -1-phenylpropane-1-one (Id) (142.1 mg, 80%)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Zhejiang University of Technology; Ling Fei; Song Dingguo; Xiao Lian; Zhong Weihui; (9 pag.)CN111004164; (2020); A;,
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