Electric Literature of 4393-09-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4393-09-3, name is (2,3-Dimethoxyphenyl)methanamine, This compound has unique chemical properties. The synthetic route is as follows.
Step 4: 1-Benzyl-N-(2,3-dimethoxybenzyl)-3-hydroxy-2-oxo-1,2-dihydropyridine-4-carboxamide (J4) The methyl ester J3 (1 equivalent) was heated at 100 C. in 2,3-dimethoxybenzylamine (35 equivalents) overnight. The reaction was cooled, diluted with water and extracted with DCM. The organic phase was dried, concentrated and the residue purified by reverse phase chromatography twice to give the desired amide J4. 1H NMR (CDCl3, 400 MHz,) delta 8.1 (1H, br. s), 7.3 (3H, m), 7.25 (2H, m), 7.0 (2H, m), 6.95 (1H, m), 6.83 (3H, m), 5.14 (2H, s), 4.64 (2H, d, J=5.6 Hz), 3.88 (3H, s), 3.84 (3H, s).
The chemical industry reduces the impact on the environment during synthesis (2,3-Dimethoxyphenyl)methanamine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P, ANGELETTI S.P.A.; MERCK & CO., INC.; US2007/155744; (2007); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem