Related Products of 366-99-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 366-99-4, name is 3-Fluoro-4-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a solution of the amine (10.05mmol) in isopropanol (20ml) was added N,N-diisopropylethylamine (1.55g, 12mmol) and 2,4,5-trichloropyrimidine (1.84g, 10mmol). The reaction mixture was reflux for 2h followed by cooling to room temperature. Water (100ml) was added and the mixture was stirred for 30min. Then the mixture was filtrated. The solid was dried to provide the title compound 2a-2u.
The synthetic route of 3-Fluoro-4-methoxyaniline has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chen, Hong; Li, Ridong; Ning, Xianling; Zhao, Xuyang; Jin, Yan; Yin, Yuxin; European Journal of Medicinal Chemistry; vol. 178; (2019); p. 141 – 153;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem