Related Products of 1484-26-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1484-26-0, name is 3-Benzyloxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Methyl 4-bromobenzoate (49 mg, 0.23 mmol) and 3 -benzyloxy aniline (50 mg, 0.25 mmol) are dissolved in dry dioxane (1 mL). Pd2(dba)3 (21 mg, 0.023 mmol), (^Bu)3PHBF4 (13 mg, 0.046 mmol) and cesium carbonate (149 mg, 0.46 mmol) are added and the mixture is degassed with bubbling Ar for 15 min. The vessel is sealed and heated at 120°C for 72 h. LiOH (IN, 0.5 mL) is added and heated at 90°C for 1 h, then is cooled, quenched with IN HCl (5 mL) and extracted into EtOAc (10 mL). The organic layer is dried (MgSO4), filtered, concentrated and purified on reverse phase HPLC (H2O/MeCN gradient) to afford the title compound 4-(3-(benzyloxy)phenylamino)benzoic acid (Hl). 1H-NMR (400 MHz, CDC13) delta = 7.96 (d, J = 8.8 Hz, 2H), 7.40 (m, 5H), 7.25 (t, J = 8.0 Hz, IH), 6.97 (d, J = 8.8 Hz, 2H), 6.81 (t, J = 2.4 Hz, IH), 6.76 (ddd, J = 1.2, 2.4, 8.0 Hz, IH), 6.71 (dd, J = 1.8 Hz, 8.0 Hz, IH), 5.07 (s, 2H). MS calcd. for C20H18NO3 (M+H+) 320.1, found 320.2.
The synthetic route of 3-Benzyloxyaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IRM LLC; WO2008/121570; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem