Related Products of 2398-37-0, The chemical industry reduces the impact on the environment during synthesis 2398-37-0, name is 1-Bromo-3-methoxybenzene, I believe this compound will play a more active role in future production and life.
General procedure: Under an argon atmosphere a solution of the appropriate bromobenzene (1 equivalent) dissolved in anhydrous THF (approximately 30 mL per mmol bromobenzene) is cooled to -78 C using a nitrogen-ethanol-bath. A solution of 2.3 equivalents of n-butyllithium in hexane is added drop wise keeping the temperature below -78 C. After completion the mixture is stirred for one hour at this temperature. Then 1.5 equivalents of trimethyl borate are added slowly and the reaction mixture is stirred at -78 C for another hour. The cooling bath is then removed, the reaction mixture is stirred until room temperature is reached and quenched with a saturated solution of ammonium chloride. THF and the major part of the water is removed under reduced pressure, the residue is laced with 3M hydrochloric acid until a pH of 3 is reached. After extraction with DCM (3 x) the organic phases are collected, washed with brine, dried over sodium sulphate and filtered. DCM is removed under reduced pressure, the resulting solid is washed first with ice cold water and then with PE and dried.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-methoxybenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Obermoser, Victoria; Mauersberger, Robert; Schuster, Daniela; Czifersky, Monika; Lipova, Marina; Siegl, Monika; Kintscher, Ulrich; Gust, Ronald; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 590 – 603;,
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