Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20469-65-2, name is 1-Bromo-3,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., COA of Formula: C8H9BrO2
Example 26; Compound No.7; (S)-2-amino-N-(5-(3-methoxy-5-(piperidin-4-yloxy)phenyl)pent-4-ynyl)pent-4-ynamide; STEP A: 3-Bromo-5-methoxyphenol; 1-Bromo-3,5-dimethoxy-benzene (0.217 g, 0.001 mol) and KCN (0.20 g, 0.003 mol) were taken up into DMSO (10 mL) and the resulting mixture stirred at 120 C. for six hours, then at 150 C. overnight. The mixture was maintained at this temperature, with stirring for another day. The reaction was then quenched with water and the resulting mixture extracted with EtOAc. The organic layer was washed with saturated NaHCO3, brine, then dried over sodium sulfate and the solvent removed in vacuo. The resulting residue was purified on normal phase chromatography (Heptane/EtOAc) to yield 3-bromo-5-methoxyphenol. MH+ 203, 205
The synthetic route of 20469-65-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Parker, Michael H.; Hlasta, Dennis J.; Huang, Yifang; Reitz, Allen B.; Lawson, Edward C.; Schubert, Carsten; Strobel, Eric; Tounge, Brett A.; White, Kimberly; Winters, Michael P.; Ghosh, Shyamali; US2011/105562; (2011); A1;,
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Ether | (C2H5)2O – PubChem