Electric Literature of 2674-34-2,Some common heterocyclic compound, 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, molecular formula is C8H8Br2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of compound Q-9 (5.0 g, 16.77 mmol) in CH3CN (50 mL) was heated to 100 0C, followed by the addition of a solution of eerie ammonium nitrate (CAN, 14 g, 25.54 mmol) in water (75 mL) over a period of 30 min. The reaction mixture was then allowed to cool to room temperature and stirred for another 30 min. The resulting precipitate was filtered, washed with water (20 mL), and dried under high vacuum to furnish compound Q-10 (2.6 g, 58%) as a yellow solid. TLC Rf = 0.4 (petroleum ether – EtOAc, 9:1); MS (ES) mlz 266 (M – H)”.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,4-Dibromo-2,5-dimethoxybenzene, its application will become more common.
Reference:
Patent; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; DJABALLAH, Hakim; ANTCZAK, Christophe; WO2010/129049; (2010); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem