Adding a certain compound to certain chemical reactions, such as: 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36805-97-7, HPLC of Formula: C11H25NO2
To a hot (800C) solution of 4-bromo-3-methyl benzoic acid (3.00 g, 13.95 mmol) in toluene (250 ml_), N,N-dimethylformamide di-terf-butyl acetal (11.35 g, 50.2 mmol) was added. The mixture was stirred at 800C for 8 h and at rt for 16 h before another portion of lambda/,lambda/-dimethylformamide di-terf-butyl acetal (5.67 g, 25.1 mmol) was added. Stirring was continued at 80C for 16 h. The mixture was cooled to rt, diluted with EA and washed with sat. aq. NaHCO3-solution followed by water. The org. layer was separated, dried over Na2SO4, filtered, evaporated and dried under high vacuum at 400C to give terf-butyl 4-bromo-3-methyl benzoate as a pale yellow oil (2.31 g). LC-MS: tR = 1.10 min; [M+1]+ = not detectable; 1H NMR (CDCI3): £ 1.61 (s, 9H), 2.46 (s, 3H), 7.59 (d, J = 8.3 Hz, 1 H), 7.66 (d, J = 8.3 Hz, 1 H), 7.86 (s, 1 H).
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Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/109904; (2009); A1;,
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