Synthetic Route of 1116-77-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1116-77-4, name is 4,4-Diethoxy-N,N-dimethyl-1-butanamine, This compound has unique chemical properties. The synthetic route is as follows.
Example 9 (0448) Synthesis of N-(4-(2-acetoxy-4-methoxybenzoyl)benzyl)-4,4-diethoxy-N,N-dimethylbutan- 1 -aminium bromide (0449) In a N2 purged 20mL weighed glass vial with stir bar is added 1 .5g (0.004mol, 1 .0 eq) of AcO-Bzp-OMe-CH2-Br prepared in Example 7 and 8 mL ethyl acetate to give a clear solution on stirring for 20mins at RT. 2.06 g 4,4-Diethoxy-N,N-dimethyl-1 -butanamine (0450) (NNDMABADEA, from TCI-America) (0.01 mol, 2.5 eq) is slowly added to the reaction solution with stirring. A precipitate is soon formed and gradually thickenes with stirring over 30- 60minutes. The reaction mixture is stirred at RT overnight. The stirring is stopped and the mixture is allowed to stand for an hour. The mixture is filtered through a coarse filter frit at around 850mbar. The precipitate is washed five times with 10ml_ ethyl acetate. The precipitate is transferred into a 10OmL rb flask with about 18ml of Dl Water. The residual organics are removed under reduced pressure to give a clear solution. The solution is filtered through a Whatman1 (1 1 urn) filter paper to give a clear solution with neutral pH, that is frozen and lyophilized to give a off white solid which is confirmed to be N-(4-(2-acetoxy-4- methoxybenzoyl)benzyl)-4,4-diethoxy-N,N-dimethylbutan-1 -aminium bromide and is stored under dry N2 in desiccator.
The chemical industry reduces the impact on the environment during synthesis 4,4-Diethoxy-N,N-dimethyl-1-butanamine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; NOVARTIS AG; CHANG, Frank; DESOUSA, Ryan; HOLLAND, Troy Vernon; LAREDO, Walter R.; (68 pag.)WO2017/93835; (2017); A1;,
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