Sources of common compounds: C7H6BrFO

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 29578-39-0, name is 1-Bromo-3-fluoro-5-methoxybenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 29578-39-0

A suspension of 3-bromo-5-fluoro-anisole (20.0 g, 97.55 mmol, 1.0 eq.), ethyl prop-2-enoate (12.6 g, 146.3 mmol, 1.5 eq.), and tri-o-tolylphosphine (2.37 g, 7.8 mmol, 8mol%) in triethylamine (175 mL) was degassed and then palladium(II) acetate (0.44 g, 1.96 mmol, 2mol%) was added to the reaction mixture. The mixture was kept at reflux temperature for 13 days (the reaction had a very slow but steady progress, during this time additional Pd-source and phosphine were added – once 2 and 8 mol% Pd and phosphine and once 1 and 4 mol% Pd and phosphine). The reaction mixture was cooled to room temperature. Volatiles were removed in vacuo, and water (300 mL) was added to the residue. The mixture was extracted with ethyl acetate (3xl50mL). The combined organic layers were washed with aq. HCl (IN, 100 mL), brine (200 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The crude material was purifed by flash column chromatography using as eluent petroleum ether/ethyl acetate 9 to 1, giving the titled compound as an off-white solid in 74% yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; KARO BIO AB; WO2009/121910; (2009); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem