Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 111-95-5, name is Bis(2-methoxyethyl)amine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 111-95-5
mixture of 4 3,6-diaminopyrazine-2,5-dicarboxylic acid (200 mg, 1.01 mmol), 5 bis-2-(methoxyethyl)amine (372 muL, 335.5 mg, 2.52 mmol), HOBt.H2O (459 mg, 3.00 mmol), and 6 EDC.HCl (575 mg, 3.00 mmol) were stirred together in 7 DMF (20 mL) for 1 h at room temperature. The mixture was concentrated to dryness and the residue was partitioned with EtOAc and water. The layers were separated and the 8 EtOAc solution was washed with saturated NaHCO3 and brine. The solution was dried over anhydrous Na2SO4, filtered and concentrated. Purification by radial flash chromatography (SiO2, 10/1 CHCl3-MeOH) afforded 228.7 mg (53% yield) of Example 1 as an orange foam: 1H NMR (300 MHz, CDCl3), delta 4.92 (s, 4H), 3.76 (apparent t, J=5.4 Hz, 4H), 3.70 (apparent t, J=5.6 Hz, 4H), 3.64 (apparent t, J=5.4 Hz, 4H), 3.565 (apparent t, J=5.4 Hz), 3.67 (s, 6H), 3.28 (s, 6H). 13C NMR (75 MHz, CDCl3) delta 167.6 (s), 145.6 (s), 131.0 (s), 72.0 (t), 70.8 (t), 59.2 (q), 49.7 (t), 47.1 (t). LCMS (5-95% gradient acetonitrile in 0.1% TFA over 10 min), single peak retention time=3.14 min on 30 mm column, (M+H)+=429. UV/vis (100 muM in PBS) lambdaabs=394 nm. Fluorescence (100 nm) lambdaex=394 nm lambdaem=550 nm.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 111-95-5.
Reference:
Patent; MediBeacon Inc.; Debreczeny, Martin P.; Rajagopalan, Raghavan; Dorshow, Richard B.; Neumann, William L.; Rogers, Thomas E.; (54 pag.)US2019/125901; (2019); A1;,
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