Synthetic Route of 126829-31-0,Some common heterocyclic compound, 126829-31-0, name is 2-Ethynyl-1,3-dimethoxybenzene, molecular formula is C10H10O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A THF solution (0.2 mL) of PdCl2(MeCN)2 (3.9 mg, 0.015 mmol) and 2b (10.2 mg, 0.015 mmol) was stirred for 10 min. To the solution were added diiodoparacyclophane 6 (0.05 mmol) in THF (0.8 mL), i-Pr2NH (0.2mL), alkyne 7 (0.2 mmol) and CuI (2.9 mg, 0.015 mmol) in order. The resulting mixture was stirred at room temperature. After the reaction was complete, H2O was added to the reaction mixture, and organic materials were extracted with AcOEt. The organic layer was washed with brine and dried with Na2SO4. The solvent was removed under reduced pressure, and the crude products were purified by thin-layer chromatography to give dialkynylated product 8.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Ethynyl-1,3-dimethoxybenzene, its application will become more common.
Reference:
Article; Kanda, Kazumasa; Oshima, Shoya; Shizuno, Tsubasa; Hamanaka, Risa; Fukai, Miku; Shibata, Takanori; Heterocycles; vol. 8; 2; (2014); p. 1355 – 1370;,
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