Application of 36805-97-7, These common heterocyclic compound, 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 1-pyrazol [1,5-b] [PYRIDAZIN-3-YLETHANONE] (8.5 g, 52.7 [MMOL)] in DMF (100 mL) was added [DIMETHYLFORMAMIDE] di-tert-butylacetal (16.1 g, 79.2 [MMOL).] The reaction was heated at an oil bath temperature of 100 [C] for about 4 hours. The solvent was removed in vacuo. The residue was triturated with diethyl ether to give the title compound as a brown solid (8 g, 70%). 1H-NMR (300 MHz, [D6-DMSO) 6] 8.76 (dd, 1H, J = 10.0, 2. [0 HZ),] 8.74 (s, [1H),] 8.61 (dd, [1 H, J = 4.] 0,2. [0 HZ),] 7.74 (d, 1H, J = 12 Hz), 7.44 (dd, [1H,] J = 10.0, 4.0 Hz), 5.87 (d, [1H,] J = 12 Hz), 3.18 (bs, 3H), 2.97 (bs, 3H); MS [(ESI)] (M+H) [+] 217.
The synthetic route of 36805-97-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2004/35588; (2004); A1;,
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