Related Products of 25245-34-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25245-34-5 name is 2-Bromo-1,4-dimethoxybenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In a 1-L round-bottom flask reactor, 2-bromo-1,4-dimethoxybenzene (50 g, 230 mmol) and tetrahydrofuran (400 ml) were dissolved. After the mixture was cooled to -78 C., it was added with drops of N-butyl lithium (167 ml, 280 mmol). At the same temperature, the mixture was stirred for 2 hrs before the addition of trimethyl borate (36 ml, 320 mmol). Stirring was conducted overnight at room temperature. After completion of the reaction, 2 N HCl was dropwise added for acidification. Extraction with water and ethyl acetate gave an organic layer which was then dried over magnesium sulfate and concentrated in a vacuum. Recrystallization in heptane and toluene afforded
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-1,4-dimethoxybenzene, and friends who are interested can also refer to it.
Reference:
Patent; SFC CO., LTD.; Cha, Soon-Wook; Park, Young-Hwan; Yoon, Seo-Yeon; Shim, So Young; (152 pag.)US2017/18723; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem