Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1535-73-5, name is 3-Trifluoromethoxyaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 3-Trifluoromethoxyaniline
General procedure: Compounds 2-amino-5-methoxy-4-substitutedbenzonitriles (4a?4d) (10.0mmol) in 10 N hydrochloric acid (30.0mL) were cooled to 0 °C and diazotized with sodium nitrite (0.71g) in water (10.0mL). The diazonium solution was neutralized with excess of sodium acetate trihydrate and stirred for 2 h at 0 °C with the corresponding substituted anilines (10.0 mmol). The solution was kept overnight at 4 °C, filtered, and washed with water. The crude products were then purified by recrystallization with ethyl acetate to obtain intermediate (5a?5z). Compounds (5a?5z) were boiled in 70percent ethanol (25.0 mL) for 1h, and then evaporated under reduced pressure to dryness. Acetic acid (10.0 mL) was added and the solution was refluxed for 2 h, cooled, poured into water (100mL), filtered and dried. The crude products thus obtained were recrystallized from ethanol to give the final compounds 7-alkoxyl-6-methoxy-4-substituted-1,2,3-benzotriazines (6a?6z).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Zhao, Xing-Wang; Liu, Dan; Luan, Sheng-Lin; Hu, Guo-Dong; Lv, Jin-Ling; Jing, Yong-Kui; Zhao, Lin-Xiang; Bioorganic and Medicinal Chemistry; vol. 21; 24; (2013); p. 7807 – 7815;,
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