Adding a certain compound to certain chemical reactions, such as: 450-88-4, name is 1-Bromo-4-fluoro-2-methoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 450-88-4, category: ethers-buliding-blocks
4-Fluoro-2-methoxybenzenethiol To a suspension of 2-bromo-5-fluoroanisole (2.00 g, 9.755 mmol) and elemental sulphur (0.468 g, 14.632 mmol) in dry THF (50 mL) was slowly added tert-butyl lithium in pentane (1.7 M, 12.6 mL, 21.46 mmol) AT-78C. The resulting suspension was allowed to stir at-78C for 60 mins before being poured onto saturated ammonium chloride solution (80 mL) and product extracted with diethyl ether (100 mL). The organic phase was washed with aqueous hydrochloric acid (2 N, 40 mL), with the resulting organic phase being dried (MgSO4) and the solvent evaporated in vacuo to give a pale yellow oil. This was treated to a pad of silica gel, eluting with hexane: ethyl acetate [95: 5] to give a pale yellow oil (1.50 g, 68%). ON (300 MHz, CDC13) 7.20 (1H, dd, Ar), 6.65-6. 55 (2H, d, AR), 3.90 (3H, s, OCH3), 3.68 (1H, s, SH).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-fluoro-2-methoxybenzene, and friends who are interested can also refer to it.
Reference:
Patent; ELI LILLY AND COMPANY; WO2004/43903; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem