Synthetic Route of 768-70-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 768-70-7, name is 3-Ethynylanisole belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step B:; In nitrogen atmosphere, the above ester (115 mg, 0.25 mmol) and 1-ethynyl-3- methoxybenzene (97 muL, 0.75 mmol) were dissolved in anhydrous tetrahydrofuran (4 mL). 0.15 M Solution of tri-tert-butylphosphine in cyclohexane (0.2 mL, 0.03 mmol) was added via syringe. Copper()) iodide (1.9 mg, 0.01 mmol), dichloro(bisbenzonitrile)palladium (5.7 mg, 0.015 mmol) and diisopropylamine (84 muL, 0.60 mmol) were added. The traces of the air were removed and the mixture was stirred under nitrogen at ambient temperature overnight. The mixture was diluted with ethyl acetate (10 mL) and filtered through a short path of silica gel. The filtrate was concentrated and purified by column chromatography (silica gel Fluka 60, hexanes/ethyl acetate 7:3 -1: 1 – 3: 7) yielding ethyl [4-[3,5-bis-(3-methoxyphenylethynyl)- phenylsulfanyl]-2-methylphenoxy]acetate. Yield: 87 mg (62 %). RF (Si02, hexanes/ethyl acetate 9:1) 0.25. , ¹H NMR spectrum (200 MHz, CDCI3, No.H) : 7.48 (t, J=1.4 Hz, 1 H) ; 7.35-7.25 (m, 6 H); 7.15- 7.01 (m, 4 H) ; 6.95-6.85 (m, 2 H) ; 6.72 (d, J=8.5 Hz, 1 H) ; 4.67 (s, 2 H) ; 4.27 (q, J=7.1 Hz, 2 H) ; 2.30 (s, 3 H); 1.29 (t, J=7.1 Hz, 3 H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Ethynylanisole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVO NORDISK A/S; WO2005/105726; (2005); A1;,
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